Department of Neurology Ljubljana - Research

Head: Prof. Zvezdan Pirtošek, MD, PhD

 

I. Employees

 

Number of physicians employed: 14 (12 neurologists, 1 psychiatrist and 1 general physician); 4 with MSc degree and 4 with PhD degree. 

Young Research Fellows: 2

Research Assistant: 1

 

II. Number of patients per year 
    (Data extrapolated from the first half of year 2011)

 

  • Out patient services: 1984 pts.
  • In patient services: 1910 pts.

 

Main patient groups:


cognitive disorders (dementia)
movement disorders
multiple sclerosis
epilepsy
autonomic disorders

 

III. Laboratories

 

  1. Laboratory for CSF

The following tests are being performed in the Laboratory for CSF: basic liquor analysis (glucose level, protein level, cell analysis, Pandy reaction); oligoclonal band analysis; CSF analysis for dementia (Aß 1-42, Tau-protein, P-TAU 182P).

 

  1. Laboratory for cognitive neuroscience

The following equipment is available in the Laboratory for cognitive neurology: 40 channel EEG- Evoked Potentials; Transcranial Magnetic Stimulation (TMS) – Magstim  BiStim2 in Magstim Rapid2.

 

  1. Movement disorders and gait analysis  lab

The following equipment is available in the Movement disorders and gait lab: Spirography (Spiralography - Wise Technologies); Moven Motion Capture System; Treadmill system for gait analysis; Actiwatch Score; posturography plate.

 

  1. Lab for autonomic neurology

     

  1. EEG lab
  2.  

  3. Neurourodynamic lab (in process of development)

 

IV. ARRS (Slovenian Research Agency) sponsored projects in last five years

 

  1. J7-6829-0312 - Mechanisms of functional brain integration underlying efficient cognitive control (G. Repovš, Project leader) - started 2014;
  2. J7-5553-0312 - Multimodal study of working memory (G. Repovš, Project leader) - started 2013;
  3. L3-4255-0312 - Early Detection and rational therapy of dementia (Z. Pirtošek, Project leader) – started 2011;
  4. J2-4222-0312  - Machine learning in building intelligent systems for knowledge acquisition (I. Bratko, Project leader)  – started 2011;
  5. L7-4274-0312 - Laser triangulation in medicine (LASTRIM) (J. Možina,  Project leader) – started 2011;
  6. J5-4230-0312  - Law and the brain – criminological, philosophical and psychoanalytical insights about the subject in the era of neuroscience (R. Salecl, Project leader) - started 2011;
  7. J3-3628-0312 - Family history – genetic tool for preventive medicine (B. Peterlin, Project leader) – started 2010;
  8. P3-0171-0381 - Poškodba, plastičnost in regeneracija živčevja in mišic (slovensko) (S. Ribarič, Project leader) - started 2009
  9. L3-9314-0312-07 - Biological markers of the neurodegenerative syndromes which manifest with parkinsonism and dementia (Z. Pirtošek, Project leader) – started 2007, finished 2010;
  10. L7-9391-0782-07 - Medical innovations with laser triangulation (J. Možina, project leader) – started 2007,  finished 2010;
  11. J7-9792 - Methodological aspects of research of the cognitive processes - learning and decision-making (A. Ule, Project leader) – started 2007, finished 2009.

 

V. Cooperation in international projects

 

  1. BMBS COST Action BM1101 - European Network for the study of dystonia syndromes – started 2011;
  2. BMBS COST Action BM0905 - European Network for the Study of Gilles de la Tourette Syndromeapplying.

 

VI. Cooperation in other international professional bodies

 

Department of Neurology is a part of:

 

  1. JPND (Joint Programming Neurodegenerative Disease) initiative;
  2. BME (Biomedical Engineering) reference center initiative.

 

VII. Selected bibliography (PubMed)

 

  1. Pirtošek Z. Myths and realities of continuous dopaminergic stimulation. Psychiatr Danub. 2011 Mar;23(1):80-3.
  2. Kramberger MG, Stukovnik V, Cus A, Repovs G, Tomse P, Meglic NP, Garasević Z, Jensterle J, Pirtosek Z. Parkinson's disease dementia: clinical correlates of brain spect perfusion and treatment. Psychiatr Danub. 2010 Sep;22(3):446-9.
  3. Ozura A, Erdberg P, Sega S. Personality characteristics of multiple sclerosis patients: a Rorschach investigation. Clin Neurol Neurosurg. 2010 Sep;112(7):629-32.
  4. Georgiev D, Danieli A, Ocepek L, Novak D, Zupancic-Kriznar N, Trost M, Pirtosek Z. Othello syndrome in patients with Parkinson's disease. Psychiatr Danub. 2010 Mar;22(1):94-8.
  5. Bartolić A, Pirtosek Z, Rozman J, Ribaric S. Tremor amplitude and tremor frequency variability in Parkinson's disease is dependent on activity and synchronisation of central oscillators in basal ganglia. Med Hypotheses. 2010 Feb;74(2):362-5. Epub 2009 Aug 4.
  6. Lovrecic L, Kastrin A, Kobal J, Pirtosek Z, Krainc D, Peterlin B. Gene expression changes in blood as a putative biomarker for Huntington's disease. Mov Disord. 2009 Nov 15;24(15):2277-81.
  7. Pirtosek Z. 'Bad guys' among the antiparkinsonian drugs'. Psychiatr Danub. 2009 Mar;21(1):114-8.
  8. Rot U. Ian McEwan--novels about neurological and psychiatric patients. Eur Neurol. 2008;60(1):12-5.
  9. Rot U, Ledinek AH, Jazbec SS. Clinical, magnetic resonance imaging, cerebrospinal fluid and electrophysiological characteristics of the earliest multiple sclerosis. Clin Neurol Neurosurg. 2008 Mar;110(3):233-8.
  10. Sega S, Horvat A, Rot U, Wraber B, Ihan A. Could cytokines levels or adhesion molecules expression be predictor of IFN-beta treatment response in multiple sclerosis patients? Clin Neurol Neurosurg. 2008 Nov;110(9):947-50.
  11. Popović M, Tavćar R, Glavac D, Volavsek M, Pirtosek Z, Vizjak A. Light chain deposition disease restricted to the brain: The first case report. Hum Pathol. 2007 Jan;38(1):179-84.
  12. Anzej S, Bozic M, Antovic A, Peternel P, Gaspersic N, Rot U, Tratar G, Stegnar M. Evidence of hypercoagulability and inflammation in young patients long after acute cerebral ischaemia. Thromb Res. 2007;120(1):39-46.
  13. Thangarajh M, Masterman T, Helgeland L, Rot U, Jonsson MV, Eide GE, Pirskanen R, Hillert J, Jonsson R.The thymus is a source of B-cell-survival factors-APRIL and BAFF-in myasthenia gravis.  Neuroimmunol. 2006 Sep;178(1-2):161-6.
  14. Trost M, Su S, Su P, Yen RF, Tseng HM, Barnes A, Ma Y, Eidelberg D. Network modulation by the subthalamic nucleus in the treatment of Parkinson's disease. Neuroimage. 2006 May 15;31(1):301-7.
  15. Ravnik J, Starovasnik B, Sesok S, Pirtosek Z, Svigelj V, Bunc G, Bosnjak R. Long-term cognitive deficits in patients with good outcomes after aneurysmal subarachnoid hemorrhage from anterior communicating artery. Croat Med J. 2006 Apr;47(2):253-63.
  16. Rot U, Mesec A.Clinical, MRI, CSF and electrophysiological findings in different stages of multiple sclerosis. Clin Neurol Neurosurg. 2006 Mar;108(3):271-4.
  17. Sega S, Horvat A, Popovic M. Anaplastic oligodendroglioma and gliomatosis type 2 in interferon-beta treated multiple sclerosis patients. Report of two cases. Clin Neurol Neurosurg. 2006 Mar;108(3):259-65.
  18. Kogoj A, Pirtosek Z, Tomori M, Vodusek DB. Event-related potentials elicited by distractors in an auditory oddball paradigm in schizophrenia. Psychiatry Res. 2005 Nov 15;137(1-2):49-59.
  19. Thangarajh M, Masterman T, Rot U, Duvefelt K, Brynedal B, Karrenbauer VD, Hillert J. Increased levels of APRIL (a proliferation-inducing ligand) mRNA in multiple sclerosis. J Neuroimmunol. 2005 Oct;167(1-2):210-4.
  20. Marchetti A, Magar R, Findley L, Larsen JP, Pirtosek Z, Růzicka E, Jech R, Sławek J, Ahmed F. Retrospective evaluation of the dose of Dysport and BOTOX in the management of cervical dystonia and blepharospasm: the REAL DOSE study. Mov Disord. 2005 Aug;20(8):937-44. Erratum in: Mov Disord. 2005 Aug;20(8):1089. Råuzizka, Evzen [corrected to Růzicka, Evzen].
  21. Sega S, Wraber B, Mesec A, Horvat A, Ihan A. IFN-beta1a and IFN-beta1b have different patterns of influence on cytokines. Clin Neurol Neurosurg. 2004 Jun;106(3):255-8.
  22. Ribaric S, Bajrovic FF, Pirtosek Z. Computer-assisted learning of neurological examination. Med Teach. 2004 Nov;26(7):665.
  23. Pirtosek Z, Flisar D. Neuroprotection and dopamine agonists. Adv Exp Med Biol. 2004;541:55-74. Review. No abstract available.
  24. Carbon M, Trost M, Ghilardi MF, Eidelberg D. Abnormal brain networks in primary torsion dystonia. Adv Neurol. 2004;94:155-61. Review. No abstract available.
  25. Frucht SJ, Trost M, Ma Y, Eidelberg D. The metabolic topography of posthypoxic myoclonus. Neurology. 2004 May 25;62(10):1879-81.
  26. Trost M, Su PC, Barnes A, Su SL, Yen RF, Tseng HM, Ma Y, Eidelberg D. Evolving metabolic changes during the first postoperative year after subthalamotomy. J Neurosurg. 2003 Nov;99(5):872-8.
  27. Rot U, Mesec A, Pogacnik T. Multiple sclerosis with uncommon cerebrospinal fluid findings. Croat Med J. 2003 Dec;44(6):697-701.
  28. Trost M. Dystonia update. Curr Opin Neurol. 2003 Aug;16(4):495-500.
  29. Herzig R, Kalvach P, Petkova V, Vuković V, Tsakadze NL, Bereczki D, Tuta S, Martiníková M, Rot U, Xhaxho S, Sidorovich E, Rand VM, Zaborski J, Gavriliuc M, Reminyak IV. The current availability of neurological in-patient services in post-communist central and eastern European countries. Neuroepidemiology. 2003 Jul-Aug;22(4):255-64.
  30. Trost M, Carbon M, Edwards C, Ma Y, Raymond D, Mentis MJ, Moeller JR, Bressman SB, Eidelberg D. Primary dystonia: is abnormal functional brain architecture linked to genotype? Ann Neurol. 2002 Dec;52(6):853-6